Applications are said to run on top of the system software, since the system software is made of "low-level" programs. While system software is automatically installed with the operating system, you can choose which applications you want to install and run on your computer.
Business software (or a business application) is any software or set of computer programs used by business users to perform various business functions. These business applications are used to increase productivity, to measure productivity, and to perform other business functions accurately.